LPA3 receptor (lpar3_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA3 receptor
GENE
LPAR3 (EDG7, LPA3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, Lysophosphatidic acid receptor Edg-7
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
E
|
C
|
H
|
Y
|
D
|
K
|
H
|
M
|
10 |
D
|
F
|
F
|
Y
|
N
|
R
|
S
|
N
|
T
|
D
|
20 |
TM1 | |||||||||
T
|
V
|
D
|
D
|
W
|
T
|
G
|
T
|
K
|
L
|
30 |
V
|
I
|
V
|
L
|
C
|
V
|
G
|
T
|
F
|
F
|
40 |
C
|
L
|
F
|
I
|
F
|
F
|
S
|
N
|
S
|
L
|
50 |
V
|
I
|
A
|
A
|
V
|
I
|
K
|
N
|
R
|
K
|
60 |
ICL1 | TM2 | ||||||||
F
|
H
|
F
|
P
|
F
|
Y
|
Y
|
L
|
L
|
A
|
70 |
N
|
L
|
A
|
A
|
A
|
D
|
F
|
F
|
A
|
G
|
80 |
I
|
A
|
Y
|
V
|
F
|
L
|
M
|
F
|
N
|
T
|
90 |
ECL1 | TM3 | ||||||||
G
|
P
|
V
|
S
|
K
|
T
|
L
|
T
|
V
|
N
|
100 |
R
|
W
|
F
|
L
|
R
|
Q
|
G
|
L
|
L
|
D
|
110 |
S
|
S
|
L
|
T
|
A
|
S
|
L
|
T
|
N
|
L
|
120 |
L
|
V
|
I
|
A
|
V
|
E
|
R
|
H
|
M
|
S
|
130 |
ICL2 | |||||||||
I
|
M
|
R
|
M
|
R
|
V
|
H
|
S
|
N
|
L
|
140 |
TM4 | |||||||||
T
|
K
|
K
|
R
|
V
|
T
|
L
|
L
|
I
|
L
|
150 |
L
|
V
|
W
|
A
|
I
|
A
|
I
|
F
|
M
|
G
|
160 |
ECL2 | |||||||||
A
|
V
|
P
|
T
|
L
|
G
|
W
|
N
|
C
|
L
|
170 |
C
|
N
|
I
|
S
|
A
|
C
|
S
|
S
|
L
|
A
|
180 |
TM5 | |||||||||
P
|
I
|
Y
|
S
|
R
|
S
|
Y
|
L
|
V
|
F
|
190 |
W
|
T
|
V
|
S
|
N
|
L
|
M
|
A
|
F
|
L
|
200 |
I
|
M
|
V
|
V
|
V
|
Y
|
L
|
R
|
I
|
Y
|
210 |
V
|
Y
|
V
|
K
|
R
|
K
|
T
|
N
|
V
|
L
|
220 |
ICL3 | TM6 | ||||||||
S
|
P
|
H
|
T
|
S
|
G
|
S
|
I
|
S
|
R
|
230 |
R
|
R
|
T
|
P
|
M
|
K
|
L
|
M
|
K
|
T
|
240 |
V
|
M
|
T
|
V
|
L
|
G
|
A
|
F
|
V
|
V
|
250 |
C
|
W
|
T
|
P
|
G
|
L
|
V
|
V
|
L
|
L
|
260 |
ECL3 | |||||||||
L
|
D
|
G
|
L
|
N
|
C
|
R
|
Q
|
C
|
G
|
270 |
TM7 | |||||||||
V
|
Q
|
H
|
V
|
K
|
R
|
W
|
F
|
L
|
L
|
280 |
L
|
A
|
L
|
L
|
N
|
S
|
V
|
V
|
N
|
P
|
290 |
H8 | |||||||||
I
|
I
|
Y
|
S
|
Y
|
K
|
D
|
E
|
D
|
M
|
300 |
Y
|
G
|
T
|
M
|
K
|
K
|
M
|
I
|
C
|
C
|
310 |
C-term | |||||||||
F
|
S
|
Q
|
E
|
N
|
P
|
E
|
R
|
R
|
P
|
320 |
S
|
R
|
I
|
P
|
S
|
T
|
V
|
L
|
S
|
R
|
330 |
S
|
D
|
T
|
G
|
S
|
Q
|
Y
|
I
|
E
|
D
|
340 |
S
|
I
|
S
|
Q
|
G
|
A
|
V
|
C
|
N
|
K
|
350 |
S
|
T
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
LPA, LYSOPHOSPHATIDIC ACID, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, farnesyl diphosphate, farnesyl monophosphate
STRUCTURE MODELS
STRUCTURES
No structures available